Triphenylphosphine → HCID 59536867, compound

HRID 220655Notes

Reaction equation

HRID 220655 reaction equation
[CH3:1][S:2]([CH2:4][CH:5]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:21])[CH3:20])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:12]([F:15])([F:14])[F:13])=O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>ClC(Cl)(Cl)Cl>[CH3:1][S:2][CH2:4][CH:5]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:21])([CH3:20])[CH3:22])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:12]([F:15])([F:14])[F:13]

Participants

4

Reactant 2

HCID 11776TriphenylphosphineHCID 59536884tert-Butyl {2-(methylsulphinyl)-1-[2-(trifluoromethyl)phenyl]ethyl}carbamate

Product 1

HCID 59536867HCID 59536867, compound

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Procedure

Of the compound from Example 108A, 400 mg (1.14 mmol), and 567 mg (2.16 mmol) of triphenylphosphine, were dissolved in 14 ml of tetrachloromethane. The reaction mixture was stirred overnight at reflux temperature and then freed from the solvent on a rotary evaporator. The residue was purified by preparative HPLC [Method 20]. The product fraction was freed from the solvent on a rotary evaporator. Drying in an HV gave 340 mg (85% of theory) of the title compound.

Workup

  1. temperatureat reflux temperature
  2. customfreed from the solvent on a rotary evaporator
  3. customThe residue was purified by preparative HPLC [Method 20]
  4. customThe product fraction was freed from the solvent on a rotary evaporator
  5. customDrying in an HV

Sources & evidence

ORD record
ord-ebc22034d37a443891cb3c1d656fcdac
Source dataset
uspto-grants-2012_06
Patent number
US08202895B2

Reaction notes

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