Dimethyl Sulfone → tert-Butyl {2-(methylsulphonyl)-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate

HRID 220662Notes

Reaction equation

HRID 220662 reaction equation
[CH3:1][S:2]([CH3:5])(=[O:4])=[O:3].[F:6][C:7]([F:24])([F:23])[C:8]1[CH:9]=[C:10](/[CH:14]=[N:15]/[C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19])[CH:11]=[CH:12][CH:13]=1>>[CH3:1][S:2]([CH2:5][CH:14]([NH:15][C:16](=[O:22])[O:17][C:18]([CH3:20])([CH3:19])[CH3:21])[C:10]1[CH:11]=[CH:12][CH:13]=[C:8]([C:7]([F:24])([F:23])[F:6])[CH:9]=1)(=[O:4])=[O:3]

Participants

3

Reactant 2

HCID 6213Dimethyl SulfoneHCID 46855703tert-butyl (NE)-N-[[3-(trifluoromethyl)phenyl]methylidene]carbamate

Product 1

HCID 59536720tert-Butyl {2-(methylsulphonyl)-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate

Procedure

From 1.50 g (15.9 mmol) of (methylsulphonyl)methane and 1.45 g (5.31 mmol) of the compound from Example 11A, using the same process as for Example 117A, 535 mg (27% of theory) of the title compound were obtained.

Sources & evidence

ORD record
ord-f03fbe80d2d24fa1aa6419acf96d2586
Source dataset
uspto-grants-2012_06
Patent number
US08202895B2

Reaction notes

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