Methyltriphenylphosphonium iodide → HCID 86685080, compound
Reaction equation
[I-].[CH3:2][P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.CC(C)([O-])C.[K+].[Cl:28][C:29]1[C:30]([F:43])=[C:31]([C:37](=O)[C:38]([F:41])([F:40])[F:39])[CH:32]=[C:33]([Cl:36])[C:34]=1[F:35]>O1CCCC1.CCCCC.O>[Cl:36][C:33]1[CH:32]=[C:31]([C:37]([C:38]([F:41])([F:40])[F:39])=[CH2:2])[C:30]([F:43])=[C:29]([Cl:28])[C:34]=1[F:35]Participants
Reactant 3
Product 1
Reagents, catalysts & solvents 3
Procedure
To the suspension of methyl triphenylphosphonium iodide (1.92 g) in tetrahydrofuran (12 ml) was added potassium tert-butoxide (0.53 g) slowly at argon atomosphere below 0° C. on ice/water bath. The reaction mixture turned to yellow and stirred for 0.5 h. To the mixture was added a solution of 1-(3,5-dichloro-2,4-difluorophenyl)-2,2,2-trifluoroethanone (1.15 g) in tetrahydrofuran (3 ml) dropwise on ice/water bath. After addition, the reaction mixture was warmed to room temperature and stirred over night. The reaction mixture was diluted with pentane and water. The organic phase was separated and washed with water and dried over MgSO4. The crude residue was purified on silica-gel column chromatography (eluent: n-hexane) to give 1,3-dichloro-2,4-difluoro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene (0.80 g).
Workup
- additionAfter addition
- stirringstirred over night
- customThe organic phase was separated
- washwashed with water
- dry with materialdried over MgSO4
- customThe crude residue was purified on silica-gel column chromatography (eluent: n-hexane)
Sources & evidence
- ORD record
- ord-426d780a63f64851a0f69f7f666a349c
- Source dataset
- uspto-grants-2016_06
- Patent number
- US09375000B2
Reaction notes
Loading…