HCID 86725460, compound → HCID 86725459, compound

HRID 2207125Notes

Reaction equation

HRID 2207125 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][N:14]([C:17]2[C:22](Br)=[C:21]([CH2:24][CH2:25][O:26][C:27]([F:30])([F:29])[F:28])[N:20]=[C:19]([C:31]([CH3:34])([CH3:33])[CH3:32])[N:18]=2)[CH2:13][CH2:12]1)=O)C1C=CC=CC=1>CC(=O)OCC.[Pd]>[C:31]([C:19]1[N:18]=[C:17]([N:14]2[CH2:15][CH2:16][NH:11][CH2:12][CH2:13]2)[CH:22]=[C:21]([CH2:24][CH2:25][O:26][C:27]([F:29])([F:30])[F:28])[N:20]=1)([CH3:34])([CH3:32])[CH3:33]

Participants

4

Reactant 1

HCID 86725460HCID 86725460, compound

Product 1

HCID 86725459HCID 86725459, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To the solution of 4-[5-bromo-2-tert-butyl-6-(2-trifluoromethoxy-ethyl)-pyrimidin-4-yl]-piperazine-1-carboxylic acid benzyl ester (26 mg, 0.048 mmol) in EA (3 mL) was added Pd/C (10.15 mg). Then the mixture was stirred for 40 min under H2 (15 psi) atmosphere. Then the mixture was concentrated and the residue was used in the next step directly.

Workup

  1. concentrationThen the mixture was concentrated

Sources & evidence

ORD record
ord-c8205012ecec49d493367e36c915c64f
Source dataset
uspto-grants-2016_06
Patent number
US09376396B2

Reaction notes

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