(2E)-2-[(3-bromo-4-pyridyl)methylene]-6,7-dimethoxy-tetralin-1-one → 2-[(3-Bromo-4-pyridyl)methyl]-6,7-dimethoxy-tetralin-1-one
Reaction equation
[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1/[CH:8]=[C:9]1/[C:10](=[O:23])[C:11]2[C:16]([CH2:17][CH2:18]/1)=[CH:15][C:14]([O:19][CH3:20])=[C:13]([O:21][CH3:22])[CH:12]=2>[Pt]>[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[CH2:8][CH:9]1[CH2:18][CH2:17][C:16]2[C:11](=[CH:12][C:13]([O:21][CH3:22])=[C:14]([O:19][CH3:20])[CH:15]=2)[C:10]1=[O:23]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
The title compound 100 is prepared according to the procedure reported in Example 36.1 with compound 84 (374 mg, 1.0 mmol) and Pt/C (5 wt % loading, 38 mg) as reactants. White solid. (Yield 0.251 g, 99%).
Sources & evidence
- ORD record
- ord-e3218ee2c9184bf2900f8cb7a9edd54e
- Source dataset
- uspto-grants-2016_06
- Patent number
- US09376387B2
Reaction notes
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