Benzyl Bromide → 2-[(3-Actyl-1-benzyl-pyridin-1-ium-4-yl)methyl]-6,7-dimethoxy-tetralin-1-one bromide

HRID 2207222Notes

Reaction equation

HRID 2207222 reaction equation
[C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][C:9]=1[CH2:10][CH:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][C:15]([O:23][CH3:24])=[C:16]([O:21][CH3:22])[CH:17]=2)[C:12]1=[O:25])(=[O:3])[CH3:2].[CH2:26]([Br:33])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[Br-:33].[C:1]([C:4]1[CH:5]=[N+:6]([CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:7]=[CH:8][C:9]=1[CH2:10][CH:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][C:15]([O:23][CH3:24])=[C:16]([O:21][CH3:22])[CH:17]=2)[C:12]1=[O:25])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 7498Benzyl BromideHCID 1185580212-[(3-Acetyl-4-pyridyl)methyl]-6,7-dimethoxy-tetralin-1-one

Product 1

HCID 1317358842-[(3-Actyl-1-benzyl-pyridin-1-ium-4-yl)methyl]-6,7-dimethoxy-tetralin-1-one bromide

Procedure

The title compound 132 is prepared according to the procedure reported in Example 38.1 with compound 104 (93 mg, 0.27 mmol) and benzyl bromide (66 μL, 0.54 mmol) as reactants. White solid. (Yield 117.1 mg, 85%).

Sources & evidence

ORD record
ord-f1995642446840129bb9f137cc4819fe
Source dataset
uspto-grants-2016_06
Patent number
US09376387B2

Reaction notes

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