Trifluoroacetic acid → HCID 73774718, compound

HRID 2207282Notes

Reaction equation

HRID 2207282 reaction equation
C(OC(=O)[N:7]([S:13]([C:16]1[CH:21]=[C:20]([Cl:22])[C:19]([O:23][C:24]2[CH:25]=[N:26][C:27]([C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=3[F:42])=[CH:28][C:29]=2[C:30]2[CH:31]=[N:32][N:33]([CH3:35])[CH:34]=2)=[CH:18][C:17]=1[F:43])(=[O:15])=[O:14])[C:8]1[N:9]=[CH:10][S:11][CH:12]=1)(C)(C)C.[F:45][C:46]([F:51])([F:50])[C:47]([OH:49])=[O:48]>ClCCl>[F:45][C:46]([F:51])([F:50])[C:47]([OH:49])=[O:48].[Cl:22][C:20]1[C:19]([O:23][C:24]2[CH:25]=[N:26][C:27]([C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=3[F:42])=[CH:28][C:29]=2[C:30]2[CH:31]=[N:32][N:33]([CH3:35])[CH:34]=2)=[CH:18][C:17]([F:43])=[C:16]([S:13]([NH:7][C:8]2[N:9]=[CH:10][S:11][CH:12]=2)(=[O:14])=[O:15])[CH:21]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 118522197HCID 118522197, compound

Product 1

HCID 73774718HCID 73774718, compoundYield 35%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

20 mg (0.03 mmol) of tert-butyl((5-chloro-2-fluoro-4-((6-(2-fluorophenyl)-4-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl)oxy)phenyl)sulfonyl)(thiazol-4-yl)carbamate was dissolved in 3 mL of dichloromethane, and 30 uL of trifluoroacetic acid was added thereto, followed by stirring at room temperature for 5 hours. After completion of the reaction as checked by TLC, the solvent was removed to obtain 7.0 mg (35% yield) of the title compound.

Workup

  1. customAfter completion of the reaction
  2. customthe solvent was removed

Sources & evidence

ORD record
ord-3c558e020d9c4b6d825e804c8af2b8c4
Source dataset
uspto-grants-2016_06
Patent number
US09376429B2

Reaction notes

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