Hydrochloric Acid → HCID 118431760, compound

HRID 2207996Notes

Reaction equation

HRID 2207996 reaction equation
C([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]2[CH:16]=[C:17]([CH:21]3[N:25]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=4[Cl:32])[N:24]=[C:23]([C:33]([F:39])([F:38])[C:34]([F:37])([F:36])[F:35])[CH2:22]3)[CH:18]=[CH:19][CH:20]=2)[CH2:10][CH2:9]1)(OC(C)(C)C)=O.Cl>C(OCC)(=O)C>[ClH:32].[Cl:32][C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=1[N:25]1[CH:21]([C:17]2[CH:18]=[CH:19][CH:20]=[C:15]([N:11]3[CH2:12][CH2:13][CH2:14][NH:8][CH2:9][CH2:10]3)[CH:16]=2)[CH2:22][C:23]([C:33]([F:39])([F:38])[C:34]([F:36])([F:37])[F:35])=[N:24]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 118431786HCID 118431786, compound

Product 1

HCID 118431760HCID 118431760, compoundYield 216%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

5-[3-(4-BOC-homopiperazin-1-yl)-phenyl]-1-(2-chloro-phenyl)-3-pentafluoroethyl-4,5-dihydro-1H-pyrazole (550.0 mg, 1.0 mmol) prepared in Example 124 was added to a saturated solution of hydrochloric acid in ethyl acetate (5.0 mL). The reaction mixture was stirred at room temperature for 3 hours and then concentrated under reduced pressure to give 550.0 mg of the titled compound as a brown liquid.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-754a61f0132c4a4c9c762f66979981d9
Source dataset
uspto-grants-2016_06
Patent number
US09376420B2

Reaction notes

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