Hydrochloric Acid → HCID 118431839, compound

HRID 2208016Notes

Reaction equation

HRID 2208016 reaction equation
C([N:8]1[CH2:13][CH:12]=[C:11]([C:14]2[CH:19]=[CH:18][N:17]=[C:16]([CH:20]3[N:24]([C:25]4[CH:30]=[CH:29][C:28]([F:31])=[CH:27][C:26]=4[F:32])[N:23]=[C:22]([C:33]([F:39])([F:38])[C:34]([F:37])([F:36])[F:35])[CH2:21]3)[CH:15]=2)[CH2:10][CH2:9]1)(OC(C)(C)C)=O.[ClH:40]>C(OCC)(=O)C>[ClH:40].[F:32][C:26]1[CH:27]=[C:28]([F:31])[CH:29]=[CH:30][C:25]=1[N:24]1[CH:20]([C:16]2[CH:15]=[C:14]([C:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH:10]=3)[CH:19]=[CH:18][N:17]=2)[CH2:21][C:22]([C:33]([F:38])([F:39])[C:34]([F:36])([F:37])[F:35])=[N:23]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 118431772HCID 118431772, compound

Product 1

HCID 118431839HCID 118431839, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

5-[4-(1-BOC-1,2,3,6-tetrahydropyridin-4-yl)-pyridin-2-yl]-1-(2,4-difluoro-phenyl)-3-pentafluoroethyl-4,5-dihydro-1H-pyrazole (500.0 mg, 6.0 mmol) prepared in Example 176 was added to a saturated solution of hydrochloric acid in ethyl acetate (20.0 mL). The reaction mixture was stirred at room temperature for 2 hours and then concentrated under reduced pressure to give 380.0 mg of the titled compound as a brown liquid.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-c4aad5bd9e394571a97e5e4895e53ffc
Source dataset
uspto-grants-2016_06
Patent number
US09376420B2

Reaction notes

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