Trifluoroacetic acid → HCID 118431668, compound

HRID 2208029Notes

Reaction equation

HRID 2208029 reaction equation
C([N:8]1[CH2:13][CH:12]=[C:11]([C:14]2[S:18][C:17]([CH:19]3[N:23]([C:24]4[CH:29]=[CH:28][C:27]([F:30])=[CH:26][C:25]=4[F:31])[N:22]=[C:21]([C:32]([F:38])([F:37])[C:33]([F:36])([F:35])[F:34])[CH2:20]3)=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)(OC(C)(C)C)=O.[F:39][C:40]([F:45])([F:44])[C:41]([OH:43])=[O:42]>ClCCl>[F:39][C:40]([F:45])([F:44])[C:41]([OH:43])=[O:42].[F:31][C:25]1[CH:26]=[C:27]([F:30])[CH:28]=[CH:29][C:24]=1[N:23]1[CH:19]([C:17]2[S:18][C:14]([C:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH:10]=3)=[CH:15][CH:16]=2)[CH2:20][C:21]([C:32]([F:37])([F:38])[C:33]([F:35])([F:36])[F:34])=[N:22]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 118431662HCID 118431662, compound

Product 1

HCID 118431668HCID 118431668, compoundYield 91.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

5-[5-(1-BOC-1,2,3,6-tetrahydropyridin-4-yl)-thiophen-2-yl]-1-(2,4-difluoro-phenyl)-3-pentafluoroethyl-4,5-dihydro-1H-pyrazole (480.0 mg, 0.85 mmol) prepared in Example 197 and trifluoroacetic acid (600.0 uL, 7.84 mmol) were added at 0° C. to dichloromethane (5.0 mL). The reaction mixture was stirred at room temperature for 3 hours and then concentrated under reduced pressure to give 450.0 mg of the titled compound as a yellow liquid.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-16d1bfc189524642ab2eb1af2d3f2d5a
Source dataset
uspto-grants-2016_06
Patent number
US09376420B2

Reaction notes

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