Hydrochloric Acid → HCID 118431866, compound

HRID 2208033Notes

Reaction equation

HRID 2208033 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[S:18][C:17]([CH:19]3[N:23]([C:24]4[CH:29]=[CH:28][C:27]([F:30])=[CH:26][C:25]=4[F:31])[N:22]=[C:21]([C:32]([F:38])([F:37])[C:33]([F:36])([F:35])[F:34])[CH2:20]3)=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)(OC(C)(C)C)=O.[ClH:39]>C(OCC)(=O)C>[ClH:39].[F:31][C:25]1[CH:26]=[C:27]([F:30])[CH:28]=[CH:29][C:24]=1[N:23]1[CH:19]([C:17]2[S:18][C:14]([N:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)=[CH:15][CH:16]=2)[CH2:20][C:21]([C:32]([F:38])([F:37])[C:33]([F:34])([F:35])[F:36])=[N:22]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 118431978HCID 118431978, compound

Product 1

HCID 118431866HCID 118431866, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

5-[5-(4-BOC-piperazin-1-yl)-thiophen-2-yl]-1-(2,4-difluoro-phenyl)-3-pentafluoroethyl-4,5-dihydro-1H-pyrazole (340.0 mg, 0.7 mmol) prepared in Example 202 was added to a saturated solution of hydrochloric acid in ethyl acetate (5.0 mL). The reaction mixture was stirred at room temperature for 2 hours and then concentrated under reduced pressure to give 300.0 mg of the titled compound as a brown liquid.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-3c9a93909c8448e9a287aabef4658e64
Source dataset
uspto-grants-2016_06
Patent number
US09376420B2

Reaction notes

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