Hydrochloric Acid → HCID 118431872, compound

HRID 2208041Notes

Reaction equation

HRID 2208041 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:15]=[C:16]([N:20]3[CH:24]([C:25]4[CH:30]=[CH:29][C:28]([F:31])=[CH:27][C:26]=4[F:32])[CH2:23][C:22]([C:33]([F:39])([F:38])[C:34]([F:37])([F:36])[F:35])=[N:21]3)[CH:17]=[CH:18][CH:19]=2)[CH2:10][CH2:9]1)(OC(C)(C)C)=O.[ClH:40]>C(OCC)(=O)C>[ClH:40].[F:32][C:26]1[CH:27]=[C:28]([F:31])[CH:29]=[CH:30][C:25]=1[CH:24]1[N:20]([C:16]2[CH:17]=[CH:18][CH:19]=[C:14]([N:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)[CH:15]=2)[N:21]=[C:22]([C:33]([F:39])([F:38])[C:34]([F:37])([F:36])[F:35])[CH2:23]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 118431981HCID 118431981, compound

Product 1

HCID 118431872HCID 118431872, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

1-[3-(4-BOC-piperazin-1-yl)-phenyl]-5-(2,4-difluoro-phenyl)-3-pentafluoroethyl-4,5-dihydro-1H-pyrazole (275.0 mg, 0.49 mmol) prepared in Example 215 was added to a saturated solution of hydrochloric acid in ethyl acetate (3.0 mL). The reaction mixture was stirred at room temperature for 2 hours and then concentrated under reduced pressure to give 240.0 mg of the titled compound as a yellow liquid.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-fa9d19b3abf54e6c8b63f1029abf95d1
Source dataset
uspto-grants-2016_06
Patent number
US09376420B2

Reaction notes

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