Hydrochloric Acid → HCID 118431921, compound

HRID 2208060Notes

Reaction equation

HRID 2208060 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH:12]([C:13]2[CH:18]=[CH:17][C:16]([N:19]3[CH2:25][CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21][CH2:20]3)=[CH:15][CH:14]=2)[CH2:11][C:10]([C:33]([C:39]([F:42])([F:41])[F:40])([C:35]([F:38])([F:37])[F:36])[OH:34])=[N:9]1.Cl>C(OCC)(=O)C>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH:12]([C:13]2[CH:14]=[CH:15][C:16]([N:19]3[CH2:25][CH2:24][CH2:23][NH:22][CH2:21][CH2:20]3)=[CH:17][CH:18]=2)[CH2:11][C:10]([C:33]([C:35]([F:37])([F:36])[F:38])([C:39]([F:41])([F:42])[F:40])[OH:34])=[N:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 118431616HCID 118431616, compound

Product 1

HCID 118431921HCID 118431921, compoundYield 148%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

1-(2-Chloro-phenyl)-5-[4-(4-BOC-homopiperazin-1-yl)-phenyl]-3-[di-(trifluoromethyl)-hydroxy-methyl]-4,5-dihydro-1H-pyrazole (350.0 mg, 0.8 mmol) prepared in Example 321 was added to a saturated solution of hydrochloric acid in ethyl acetate (5.0 mL). The reaction mixture was stirred at room temperature for 2 hours and then concentrated under reduced pressure to give 330.0 mg of the titled compound as a pale yellow solid.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-e21c0df70f804575a16b4d7c66fd92d8
Source dataset
uspto-grants-2016_06
Patent number
US09376420B2

Reaction notes

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