1-Bromohexane → HCID 136128428, compound

HRID 220808Notes

Reaction equation

HRID 220808 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].Cl.[Cl:9][C:10]1[CH:11]=[CH:12][C:13]2[N:22]([C:23]([CH:25]3[CH2:30][CH2:29][CH:28]([CH2:31][NH:32][C:33](=[O:42])[CH2:34][CH2:35][CH:36]4[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]4)[CH2:27][CH2:26]3)=[O:24])[CH2:21][C:20]3[CH:19]=[N:18][N:17]([CH3:43])[C:16]=3[NH:15][C:14]=2[CH:44]=1>CN(C=O)C.C(N(CC)CC)C>[Cl:9][C:10]1[CH:11]=[CH:12][C:13]2[N:22]([C:23]([CH:25]3[CH2:30][CH2:29][CH:28]([CH2:31][NH:32][C:33](=[O:42])[CH2:34][CH2:35][CH:36]4[CH2:37][CH2:38][N:39]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7])[CH2:40][CH2:41]4)[CH2:27][CH2:26]3)=[O:24])[CH2:21][C:20]3[CH:19]=[N:18][N:17]([CH3:43])[C:16]=3[NH:15][C:14]=2[CH:44]=1

Participants

5

Reactant 2

HCID 81011-BromohexaneHCID 136346636HCID 136346636, compound

Product 1

HCID 136128428HCID 136128428, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolvent2×HCID 8471TriethylamineSolvent

Procedure

A solution of 1-bromohexane (0.83 mg, 0.005 mmol) in DMF (0.05 ml) was added to a solution of N-[4-(6-chloro-3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-cyclohexylmethyl]-3-piperidin-4-yl-propionamide hydrochloride (Compound number 237) (2.57 mg, 0.005 mmol) in DMF (0.05 ml) and triethylamine (0.0021 ml). The mixture was stirred for 20 h at room temperature then solvents were removed in vacuo to yield the title compound. (ESI)+: [M+H]+=597.6/599.6

Workup

  1. customsolvents were removed in vacuo

Sources & evidence

ORD record
ord-3d5a859a061142f9a2823f9ddc36421f
Source dataset
uspto-grants-2012_06
Patent number
US08202858B2

Reaction notes

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