Hydrochloric Acid → HCID 118431989, compound

HRID 2208087Notes

Reaction equation

HRID 2208087 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH:13]([C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH2:25][CH2:24][N:23](C(OC(C)(C)C)=O)[CH2:22][CH2:21]3)=[CH:16][CH:15]=2)[CH2:12][C:11]([C:33]([C:39]([F:42])([F:41])[F:40])([C:35]([F:38])([F:37])[F:36])[OH:34])=[N:10]1.[ClH:43]>C(OCC)(=O)C>[ClH:43].[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH:13]([C:14]2[CH:15]=[CH:16][C:17]([N:20]3[CH2:21][CH2:22][NH:23][CH2:24][CH2:25]3)=[CH:18][CH:19]=2)[CH2:12][C:11]([C:33]([C:35]([F:36])([F:37])[F:38])([C:39]([F:41])([F:40])[F:42])[OH:34])=[N:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 118431619HCID 118431619, compound

Product 1

HCID 118431989HCID 118431989, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

1-(2,4-Difluoro-phenyl)-5-[4-(4-BOC-piperazin-1-yl)-phenyl]-3-[di-(trifluoromethyl)-hydroxy-methyl]-4,5-dihydro-1H-pyrazole (340.0 mg, 0.6 mmol) prepared in Example 404 was added to a saturated solution of hydrochloric acid in ethyl acetate (5.0 mL). The reaction mixture was stirred at room temperature for 2 hours and then concentrated under reduced pressure to give 300.0 mg of the titled compound as a pale yellow solid.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-af24baac429c4a5b971db5f627bc1c5f
Source dataset
uspto-grants-2016_06
Patent number
US09376420B2

Reaction notes

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