反应详情

温度

80 °C

To a stirred solution of methyl 3-bromo-5-(cyclopentylamino)benzoate (0.3 g, 0.96 mmol) in DMF (5 mL), cesium carbonate (0.628 g, 1.92 mmol) and ethyl iodide (0.748 g, 4.8 mmol) were added; resulting reaction mass was heated at 80° C. for 24 h. On completion, reaction mass was cooled to room temperature and filtered, residue was washed with ethyl acetate and filtrate was concentrated and then purified by column chromatography to afford desired compound (0.150 g, 46%).

1. customresulting
2. customreaction mass
3. customOn completion, reaction mass
4. temperaturewas cooled to room temperature
5. filtrationfiltered
6. washresidue was washed with ethyl acetate and filtrate
7. concentrationwas concentrated
8. custompurified by column chromatography