反应详情

温度

60 °C

To stirred solution of 5-bromo-2,4-dimethyl-3-nitrobenzoic acid (13 g, 47.44 mmol) in DMF (120 mL), sodium carbonate (15 g, 142.2 mmol) and methyl iodide (4.4 ml, 71.16 mmol) were added. Resulting reaction mass was heated at 60° C. for 8 h. On completion, water was added to the reaction mass and extraction was carried out using ethyl acetate. Combined organic layers were washed with sat. bicarbonate solution and 5 N HCl, dried over sodium sulphate, concentrated under reduced pressure giving desired compound (12.9 g, 86%).

1. additionwere added
2. customResulting
3. customreaction mass
4. washCombined organic layers were washed with sat. bicarbonate solution and 5 N HCl
5. dry with materialdried over sodium sulphate
6. concentrationconcentrated under reduced pressure