1-Bromohexane → HCID 136128390, compound

HRID 220876Notes

Reaction equation

HRID 220876 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].Cl.Cl.[Cl:10][C:11]1[CH:12]=[CH:13][C:14]2[N:23]([C:24]([C:26]3[CH:31]=[CH:30][C:29]([O:32][CH2:33][CH2:34][CH2:35][N:36]4[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]4)=[CH:28][C:27]=3[F:42])=[O:25])[CH2:22][C:21]3[CH:20]=[N:19][N:18]([CH3:43])[C:17]=3[NH:16][C:15]=2[CH:44]=1>CN(C=O)C.C(N(CC)CC)C>[Cl:10][C:11]1[CH:12]=[CH:13][C:14]2[N:23]([C:24]([C:26]3[CH:31]=[CH:30][C:29]([O:32][CH2:33][CH2:34][CH2:35][N:36]4[CH2:41][CH2:40][N:39]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7])[CH2:38][CH2:37]4)=[CH:28][C:27]=3[F:42])=[O:25])[CH2:22][C:21]3[CH:20]=[N:19][N:18]([CH3:43])[C:17]=3[NH:16][C:15]=2[CH:44]=1

Participants

5

Reactant 2

HCID 81011-BromohexaneHCID 136346639HCID 136346639, compound

Product 1

HCID 136128390HCID 136128390, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolvent2×HCID 8471TriethylamineSolvent

Procedure

A solution of 1-bromohexane (0.83 mg, 0.005 mmol) in DMF (0.05 ml) was added to a solution of (6-chloro-3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulen-9-yl)-[2-fluoro-4-(3-piperazin-1-yl-propoxy)-phenyl]-methanone dihydrochloride from Example E5a (2.85 mg, 0.005 mmol) in DMF (0.05 ml) and triethylamine (0.0021 ml). The mixture was stirred for 20 h at room temperature then solvents were removed in vacuo to yield the title compound. (ESI)+: [M+H]+=583.6

Workup

  1. customsolvents were removed in vacuo

Sources & evidence

ORD record
ord-c158ea85e14b4cbbaef012527eb76c3f
Source dataset
uspto-grants-2012_06
Patent number
US08202858B2

Reaction notes

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