1-Bromohexane → HCID 136128359, compound

HRID 220883Notes

Reaction equation

HRID 220883 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[CH3:8][C:9]1[CH:14]=[C:13]([C:15]([N:17]2[CH2:26][C:25]3[CH:24]=[N:23][N:22]([CH3:27])[C:21]=3[NH:20][C:19]3[CH:28]=[CH:29][CH:30]=[CH:31][C:18]2=3)=[O:16])[CH:12]=[CH:11][C:10]=1[CH2:32][CH2:33][C:34]([N:36]1[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]1)=[O:35]>CN(C=O)C.C(N(CC)CC)C>[CH2:2]([N:39]1[CH2:38][CH2:37][N:36]([C:34](=[O:35])[CH2:33][CH2:32][C:10]2[CH:11]=[CH:12][C:13]([C:15]([N:17]3[CH2:26][C:25]4[CH:24]=[N:23][N:22]([CH3:27])[C:21]=4[NH:20][C:19]4[CH:28]=[CH:29][CH:30]=[CH:31][C:18]3=4)=[O:16])=[CH:14][C:9]=2[CH3:8])[CH2:41][CH2:40]1)[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

Participants

5

Reactant 2

HCID 81011-BromohexaneHCID 136128343HCID 136128343, compound

Product 1

HCID 136128359HCID 136128359, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolvent2×HCID 8471TriethylamineSolvent

Procedure

A solution of 1-bromohexane (0.83 mg, 0.005 mmol) in DMF (0.05 ml) was added to a solution of 3-[2-methyl-4-(3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-phenyl]-1-piperazin-1-yl-propan-1-one from Example E47 (2.29 mg, 0.005 mmol) in DMF (0.05 ml) and triethylamine (0.0021 ml). The mixture was stirred for 20 h at room temperature then solvents were removed in vacuo to yield the title compound. (ESI)+: [M+H]+=543.4

Workup

  1. customsolvents were removed in vacuo

Sources & evidence

ORD record
ord-cfab8a733e1c40d4b45662134b57dc67
Source dataset
uspto-grants-2012_06
Patent number
US08202858B2

Reaction notes

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