Acetyl chloride → HCID 136128401, compound

HRID 220885Notes

Reaction equation

HRID 220885 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[Cl:5][C:6]1[CH:7]=[CH:8][C:9]2[N:18]([C:19]([C:21]3[CH:26]=[CH:25][C:24]([CH2:27][CH2:28][C:29]([N:31]4[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]4)=[O:30])=[C:23]([CH3:37])[CH:22]=3)=[O:20])[CH2:17][C:16]3[CH:15]=[N:14][N:13]([CH3:38])[C:12]=3[NH:11][C:10]=2[CH:39]=1>ClCCl.C(N(CC)CC)C>[C:1]([N:34]1[CH2:33][CH2:32][N:31]([C:29](=[O:30])[CH2:28][CH2:27][C:24]2[CH:25]=[CH:26][C:21]([C:19]([N:18]3[CH2:17][C:16]4[CH:15]=[N:14][N:13]([CH3:38])[C:12]=4[NH:11][C:10]4[CH:39]=[C:6]([Cl:5])[CH:7]=[CH:8][C:9]3=4)=[O:20])=[CH:22][C:23]=2[CH3:37])[CH2:36][CH2:35]1)(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 6367Acetyl chlorideHCID 136128355HCID 136128355, compound

Product 1

HCID 136128401HCID 136128401, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolvent2×HCID 8471TriethylamineSolvent

Procedure

A solution of acetyl chloride (0.39 mg, 0.005 mmol) in dichloromethane (0.05 ml) was added to a solution of 3-[4-(6-chloro-3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-2-methyl-phenyl]-1-piperazin-1-yl-propan-1-one (2.47 mg, 0.005 mmol) in di-chloromethane (0.05 ml) and triethylamine (0.0035 ml). The mixture was stirred at room temperature for 20 h then solvents were removed in vacuo to yield the title compound. (ESI)+: [M+H]+=535.5

Workup

  1. customsolvents were removed in vacuo

Sources & evidence

ORD record
ord-45a695ef379a485693ce042b000377a1
Source dataset
uspto-grants-2012_06
Patent number
US08202858B2

Reaction notes

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