Trifluoroacetic acid → HCID 117843220, compound

HRID 2209193Notes

Reaction equation

[C:1](O)([C:3](F)(F)F)=[O:2].[CH3:8][O:9][C:10]1[N:15]=[C:14]([C:16]2[CH:17]=[C:18]([O:25][C@@H:26]([C@H:28]3[CH2:32][NH:31][C:30](=[O:33])[CH2:29]3)[CH3:27])[C:19]3[S:23][CH:22]=[N:21][C:20]=3[CH:24]=2)[CH:13]=[CH:12][C:11]=1[N:34]1[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1>>[C:1]([N:37]1[CH2:36][CH2:35][N:34]([C:11]2[CH:12]=[CH:13][C:14]([C:16]3[CH:17]=[C:18]([O:25][C@@H:26]([C@H:28]4[CH2:32][NH:31][C:30](=[O:33])[CH2:29]4)[CH3:27])[C:19]4[S:23][CH:22]=[N:21][C:20]=4[CH:24]=3)=[N:15][C:10]=2[O:9][CH3:8])[CH2:39][CH2:38]1)(=[O:2])[CH3:3]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 117843463HCID 117843463, compound

Product 1

HCID 117843220HCID 117843220, compound

Procedure

(R)-4-((R)-1-((5-(5-(4-acetylpiperazin-1-yl)-6-methoxypyridin-2-yl)benzo[d]thiazol-7-yl)oxy)ethyl)pyrrolidin-2-one 4.39 was prepared using a procedure analogous to that described for Example 4.31 starting with the TFA salt of (R)-4-((R)-1-((5-(6-methoxy-5-(piperazin-1-yl)pyridin-2-yl)benzo[d]thiazol-7-yl)oxy)ethyl)pyrrolidin-2-one 4.38.

Sources & evidence

ORD record: ord-cc8f4148ed44458481abafddf18dd33e
Source dataset: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09376441B2

Reaction notes

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