Ethanesulfonyl chloride → HCID 136128421, compound

HRID 220950Notes

Reaction equation

HRID 220950 reaction equation
[CH2:1]([S:3](Cl)(=[O:5])=[O:4])[CH3:2].Cl.[Cl:8][C:9]1[CH:10]=[CH:11][C:12]2[N:21]([C:22]([C:24]3[CH:41]=[CH:40][C:27]([CH2:28][NH:29][C:30](=[O:39])[CH2:31][CH2:32][CH:33]4[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]4)=[CH:26][C:25]=3[CH3:42])=[O:23])[CH2:20][C:19]3[CH:18]=[N:17][N:16]([CH3:43])[C:15]=3[NH:14][C:13]=2[CH:44]=1>ClCCl.C(N(CC)CC)C>[Cl:8][C:9]1[CH:10]=[CH:11][C:12]2[N:21]([C:22]([C:24]3[CH:41]=[CH:40][C:27]([CH2:28][NH:29][C:30](=[O:39])[CH2:31][CH2:32][CH:33]4[CH2:38][CH2:37][N:36]([S:3]([CH2:1][CH3:2])(=[O:5])=[O:4])[CH2:35][CH2:34]4)=[CH:26][C:25]=3[CH3:42])=[O:23])[CH2:20][C:19]3[CH:18]=[N:17][N:16]([CH3:43])[C:15]=3[NH:14][C:13]=2[CH:44]=1

Participants

5

Reactant 2

HCID 11667Ethanesulfonyl chlorideHCID 136346647HCID 136346647, compound

Product 1

HCID 136128421HCID 136128421, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolvent2×HCID 8471TriethylamineSolvent

Procedure

A solution of ethanesulfonyl chloride (0.64 mg, 0.005 mmol) in dichloromethane (0.05 ml) was added to a solution of N-[4-(6-chloro-3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-3-methyl-benzyl]-3-piperidin-4-yl-propionamide hydrochloride (Compound number 1108) (2.97 mg, 0.005 mmol) in dichloro-methane (0.05 ml) and triethylamine (0.0035 ml). The mixture was stirred at room temperature for 1 h then sol-vents were removed in vacuo to yield the title compound. (ESI)+: [M+H]+=613.4

Workup

  1. customthen sol-vents were removed in vacuo

Sources & evidence

ORD record
ord-8207e2e667ab404fa6f2b92dcca6345c
Source dataset
uspto-grants-2012_06
Patent number
US08202858B2

Reaction notes

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