反应详情

温度

60 °C

A mixture consisting of 6.88 g (30.35 mmol) 5,7-dihydroxy-2-methylthiochromone, 12.56 g (91.05 mmol) potassium carbonate, 6.07 ml (60.70 mmol) isopropyl iodide, and 150 ml DMF was stirred at 60° C. for 30 min. Subsequently, 5 added to the solution thus reacted. The product was extracted twice with ethyl acetate. organic layer was washed with saturated salt water and dried over sodium sulfate anhydride. The solvent was distilled out under reduced pressure. The resulting crude product was purified by flash column cliromatography (hexane ethyl acetate =4:1), whereby 6.71 g of 5-hydroxy-7-isopropoxy-2-methylthiochromone was obtained (yield: 83%).

1. additionSubsequently, 5 added to the solution
2. customthus reacted
3. extractionThe product was extracted twice with ethyl acetate
4. washorganic layer was washed with saturated salt water
5. dry with materialdried over sodium sulfate anhydride
6. distillationThe solvent was distilled out under reduced pressure
7. customThe resulting crude product was purified by flash column cliromatography (hexane ethyl acetate =4:1)