反应详情

温度

0 °C

4-Cyano-3-methyl-N-(4-trifluoromethyl-phenyl)-benzamide from Example E118.1 (1.10 g, 3.6 mmol) was dissolved in DMF (10 ml) and cooled down to 0° C. Sodium hydride (60% dispersion in oil, 174 mg, 4.3 mmol) was added and the mixture was stirred for 30 min at room temperature. Methyl iodide (0.27 ml, 4.3 mmol) was added and the mixture was stirred for 20 h. Solvents were removed in vacuo and azeotroped with toluene. The residue was re-dissolved in EtOAc, washed with brine, dried and concentrated in vacuo to yield the title compound (1.08 g, 94%).

1. stirringthe mixture was stirred for 20 h
2. customSolvents were removed in vacuo
3. customazeotroped with toluene
4. dissolutionThe residue was re-dissolved in EtOAc
5. washwashed with brine
6. customdried
7. concentrationconcentrated in vacuo