1-Chloro-1-chloromethyl-1-silacyclopentane → HCID 19382018, compound

HRID 2209825Notes

Reaction equation

HRID 2209825 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[Mg]Br.Cl[Si:12]1([CH2:17][Cl:18])[CH2:16][CH2:15][CH2:14][CH2:13]1>C1COCC1>[Cl:18][CH2:17][Si:12]1([C:3]2[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=2[F:1])[CH2:16][CH2:15][CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 193820151-Chloro-1-chloromethyl-1-silacyclopentaneHCID 178505836HCID 178505836, compound

Product 1

HCID 19382018HCID 19382018, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the same apparatus and procedures as Example 4-ii) was prepared 15.3 g (0.079 mol) of 2,4-difluorophenylmagnesiumbromide solution in THF, and the followed by coupling with 1-chloro-1-chloromethyl-1-silacyclopentane prepared from the above procedure i) for 1hr at 60° C. In the same method as Example 1 was treated the reaction product to give 3.5 g of 1-chloromethyl -1-(2,4-difluorophenyl)-1-silacyclopentane (56°-7° C. /0.3 mmHg).

Workup

  1. customprepared from the above procedure i) for 1hr at 60° C
  2. additionIn the same method as Example 1 was treated the reaction product

Sources & evidence

ORD record
ord-a7326fb7ec014513a101d48912a2506b
Source dataset
uspto-grants-1995_10
Patent number
US05455356

Reaction notes

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