Sodium Iodide → HCID 145822282, compound

HRID 2209873Notes

Reaction equation

HRID 2209873 reaction equation
[CH2:1]([O:8][C:9]([NH:11][C:12]([C:14]1[CH:15]=[CH:16][C:17]([C:20]2[CH:25]=[CH:24][C:23]([O:26][CH2:27][C@H:28]3[NH:32][C:31](=[O:33])[C@H:30]([CH2:34][C:35]([OH:37])=[O:36])[CH2:29]3)=[CH:22][CH:21]=2)=[N:18][CH:19]=1)=[NH:13])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.ClC[CH2:40][C:41]([CH3:46])([CH3:45])[C:42]([O-:44])=[O:43].[C:47](=O)([O-])[O-].[K+].[K+].[I-].[Na+]>CS(C)=O>[CH2:1]([O:8][C:9]([NH:11][C:12]([C:14]1[CH:15]=[CH:16][C:17]([C:20]2[CH:25]=[CH:24][C:23]([O:26][CH2:27][C@H:28]3[NH:32][C:31](=[O:33])[C@H:30]([CH2:34][C:35]([O:37][CH2:47][O:44][C:42](=[O:43])[C:41]([CH3:46])([CH3:45])[CH3:40])=[O:36])[CH2:29]3)=[CH:22][CH:21]=2)=[N:18][CH:19]=1)=[NH:13])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

6

Reactant 4

HCID 5238Sodium IodideHCID 11430Potassium CarbonateHCID 217530474-Chloro-2,2-dimethylbutanoateHCID 139628146HCID 139628146, compound

Product 1

HCID 145822282HCID 145822282, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Prepared from (3S,5S)-5-[[4-(5-benzyloxycarbonylamidino-2-pyridyl)phenyl]oxymethyl]-3-carboxymethyl-2-pyrrolidinone by reacting with chloromethylpivalate in dimethylsulphoxide in the presence of potassium carbonate and sodium iodide.

Sources & evidence

ORD record
ord-eac5c7f78cd945bf8a43fa97f4a2f53c
Source dataset
uspto-grants-1995_10
Patent number
US05455348

Reaction notes

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