Hydrochloric Acid → HCID 22856457, compound

HRID 2209874Notes

Reaction equation

HRID 2209874 reaction equation
C(OC([NH:11][C:12]([C:14]1[CH:15]=[CH:16][C:17]([C:20]2[CH:25]=[CH:24][C:23]([O:26][CH2:27][C@H:28]3[NH:32][C:31](=[O:33])[C@H:30]([CH2:34][C:35]([O:37][CH2:38][O:39][C:40](=[O:45])[C:41]([CH3:44])([CH3:43])[CH3:42])=[O:36])[CH2:29]3)=[CH:22][CH:21]=2)=[N:18][CH:19]=1)=[NH:13])=O)C1C=CC=CC=1.[ClH:46]>[Pd].CN(C)C=O>[ClH:46].[C:12]([C:14]1[CH:15]=[CH:16][C:17]([C:20]2[CH:21]=[CH:22][C:23]([O:26][CH2:27][C@H:28]3[NH:32][C:31](=[O:33])[C@H:30]([CH2:34][C:35]([O:37][CH2:38][O:39][C:40](=[O:45])[C:41]([CH3:43])([CH3:42])[CH3:44])=[O:36])[CH2:29]3)=[CH:24][CH:25]=2)=[N:18][CH:19]=1)(=[NH:11])[NH2:13]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 145822282HCID 145822282, compound

Product 1

HCID 22856457HCID 22856457, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 6228DimethylformamideSolvent

Procedure

Prepared from (3S,5S)-5-[[4-(5-benzyloxycarbonylamidino-2-pyridyl)phenyl]oxymethyl]-3-[(pivaloyloxymethyloxycarbonyl)-methyl]-2-pyrrolidinone by hydrogenation with palladium on charcoal in dimethylformamide in the presence of hydrochloric acid.

Sources & evidence

ORD record
ord-e196daa4b6e94dd9b8a8fb040dc1f877
Source dataset
uspto-grants-1995_10
Patent number
US05455348

Reaction notes

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