Methyl p-toluenesulfonate → HCID 19378707, compound

HRID 2210464Notes

Reaction equation

HRID 2210464 reaction equation
[CH3:1][C:2]1[CH:11]=[N:10][C:9]2[S:8](=[O:13])(=[O:12])[N:7]=[CH:6][NH:5][C:4]=2[CH:3]=1.[C:14](=O)([O-])[O-].[K+].[K+].C1(C)C=CC(S(OC)(=O)=O)=CC=1>C(#N)C.O>[CH3:14][N:5]1[C:4]2[CH:3]=[C:2]([CH3:1])[CH:11]=[N:10][C:9]=2[S:8](=[O:13])(=[O:12])[N:7]=[CH:6]1

Participants

6

Reactant 3

HCID 6645Methyl p-toluenesulfonateHCID 11430Potassium CarbonateHCID 19378715HCID 19378715, compound

Product 1

HCID 19378707HCID 19378707, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6342AcetonitrileSolvent

Procedure

A solution of 0.6 g of 6-methyl-4H-pyrido[3,2-e][1,2,4]thiadiazine 1,1-dioxide (Example 75) in 15 cm3 of acetonitrile is treated with 2.5 g of potassium carbonate and 0.9 g of methyl p-toluenesulfonate. After refluxing for 16 hours, the solvent is removed under partial vacuum and the solid obtained is taken up in 15 cm3 of water. The precipitate is collected on a filter, washed with water and dried.

Workup

  1. temperatureAfter refluxing for 16 hours
  2. customthe solvent is removed under partial vacuum
  3. customthe solid obtained
  4. customThe precipitate is collected on a filter
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-7896bfbd691240e18b31edff0efd93ba
Source dataset
uspto-grants-1995_10
Patent number
US05459138

Reaction notes

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