Ethyl Bromide → HCID 19378727, compound

HRID 2210466Notes

Reaction equation

HRID 2210466 reaction equation
[CH3:1][C:2]1[CH:11]=[N:10][C:9]2[S:8](=[O:13])(=[O:12])[N:7]=[CH:6][NH:5][C:4]=2[CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:20](Br)[CH3:21]>C(#N)C.O>[CH2:20]([N:5]1[C:4]2[CH:3]=[C:2]([CH3:1])[CH:11]=[N:10][C:9]=2[S:8](=[O:13])(=[O:12])[N:7]=[CH:6]1)[CH3:21]

Participants

6

Reactant 3

HCID 6332Ethyl BromideHCID 11430Potassium CarbonateHCID 19378715HCID 19378715, compound

Product 1

HCID 19378727HCID 19378727, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6342AcetonitrileSolvent

Procedure

A solution of 1.2 g of 6-methyl-4H-pyrido[3,2-e][1,2,4]thiadiazine 1,1-dioxide (Example 75) in 15 cm3 of acetonitrile is treated with 2.5 g of potassium carbonate and 2 g of ethyl bromide. After refluxing for 16 hours, the solvent is removed under partial vacuum and the solid obtained is taken up in 15 cm3 of water. The precipitate is collected on a filter, washed with water and dried.

Workup

  1. temperatureAfter refluxing for 16 hours
  2. customthe solvent is removed under partial vacuum
  3. customthe solid obtained
  4. customThe precipitate is collected on a filter
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-e9c28aa648424194a93d982bab65ae5b
Source dataset
uspto-grants-1995_10
Patent number
US05459138

Reaction notes

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