Morpholine → 173158-11-7

HRID 2210470Notes

Reaction equation

HRID 2210470 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]([S:10](F)(=[O:12])=[O:11])[CH:7]=[CH:8][CH:9]=1)(=[O:3])[CH3:2].[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>C1COCC1>[C:1]([C:4]1[CH:5]=[C:6]([S:10]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)(=[O:12])=[O:11])[CH:7]=[CH:8][CH:9]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 8083MorpholineHCID 12821Acetylbenzenesulfonyl fluoride

Product 1

HCID 962213173158-11-7

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 20.02 g (0.1 mol) of 3-acetylbenzenesulfonyl fluoride and 29 ml of morpholine in 100 mL of THF is stirred at room temperature for 16 hours. The solvent is removed, the residue dissolved in CH2C2, and solution washed with H20 and 2N HCl. The organic layer is dried (MgSO4), the solvent removed, and the residue crystallized from CH2Cl2 -hexane to give 25.2 g (93%) of light yellow crystals, m.p. 144°-147° C.

Workup

  1. customThe solvent is removed
  2. dissolutionthe residue dissolved in CH2C2, and solution
  3. washwashed with H20 and 2N HCl
  4. dry with materialThe organic layer is dried (MgSO4)
  5. customthe solvent removed
  6. customthe residue crystallized from CH2Cl2 -hexane
  7. customto give 25.2 g (93%) of light yellow crystals, m.p. 144°-147° C.

Sources & evidence

ORD record
ord-c2644188701d44138328be6033010647
Source dataset
uspto-grants-1995_10
Patent number
US05459131

Reaction notes

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