Aluminium lithium hydride → HCID 15295460, compound

HRID 2210536Notes

Reaction equation

HRID 2210536 reaction equation
[CH:1]1([O:6][C:7]2[CH:8]=[C:9]([CH:15]3[CH2:20][C:19](=O)[NH:18][C:17](=O)[CH2:16]3)[CH:10]=[CH:11][C:12]=2[O:13][CH3:14])[CH2:5][CH2:4][CH2:3][CH2:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1COCC1>[CH:1]1([O:6][C:7]2[CH:8]=[C:9]([CH:15]3[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]3)[CH:10]=[CH:11][C:12]=2[O:13][CH3:14])[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 21952902HCID 21952902, compound

Product 1

HCID 15295460HCID 15295460, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following the procedure of Nacci et al, Vide Supra, reaction of 4(3-cyclopentyloxy-4-methoxyphenyl)-2,6-piperidinedione (12 mmol, 3.65 g) and lithium aluminum hydride (120 mmol, 4.56 g) in dry THF (240 mL) afforded the title compound as a light yellow waxy solid (2.71 g, 82%) of sufficient purity for subsequent transformations.

Sources & evidence

ORD record
ord-5d935a2148ab473d83dc7e6d61ceb424
Source dataset
uspto-grants-1995_10
Patent number
US05459151

Reaction notes

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