反应详情

In the same manner as Example, 9, 3-[4-(3-cyclopentyloxy-4-methoxyphenyl)piperidin-1-yl]-3-oxo-propionic acid (0.70 mmol, 0.25 g), oxalyl chloride (0.77 mmol, 0.385 mL; 2M solution in CH2Cl2), DMF (4 drops) and saturated NH3 /CH3CN solution (10 mL) in dry toluene (10 mL) afforded a solid which was triturated in Et2O/hexane to give the title compound as a white solid, mp=132°-133° C. (0.40 mmol, 0.150 g, 60%).

1. customwas triturated in Et2O/hexane