Potassium Carbonate → HCID 15293909, compound

HRID 2210571Notes

Reaction equation

HRID 2210571 reaction equation
[OH:1][CH:2]([C:7]1[N:8]=[C:9]([CH2:14][CH2:15][CH3:16])[NH:10][C:11]=1[C:12]#[N:13])[C:3]([CH3:6])([CH3:5])[CH3:4].Br[CH2:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[C:31](=[O:36])[C:32]([O:34]C)=[O:33])=[CH:21][CH:20]=1.C(=O)([O-])[O-:38].[K+].[K+]>>[OH:1][CH:2]([C:7]1[N:8]=[C:9]([CH2:14][CH2:15][CH3:16])[N:10]([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[C:31]([C:32]([OH:34])=[O:33])=[O:36])=[CH:21][CH:20]=2)[C:11]=1[C:12]([NH2:13])=[O:38])[C:3]([CH3:4])([CH3:5])[CH3:6]

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 19379004HCID 19379004, compoundHCID 178440145HCID 178440145, compound

Product 1

HCID 15293909HCID 15293909, compoundYield 70.2%

Procedure

Following a procedure similar to that described in Example 10(a), but using 170 mg of 4-(1-hydroxy-2,2-dimethylpropyl)-2-propylimidazole-5-carbonitrile, 307 mg of methyl (4'-bromomethylbiphenyl-2-yl)glyoxylate (prepared as described in Preparation 8) and 106 mg of potassium carbonate, 257 mg of the title compound were obtained as crystals, melting at 128°-130° C.

Sources & evidence

ORD record
ord-b86d0a6a041a4bc3837b8bf7eff8f636
Source dataset
uspto-grants-1995_10
Patent number
US05459148

Reaction notes

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