Lithium hydroxide, monohydrate → HCID 19378987, compound

HRID 2210575Notes

Reaction equation

HRID 2210575 reaction equation
[CH2:1]([O:3][CH2:4][C:5]1[N:6]([CH2:19][C:20]2[CH:25]=[CH:24][C:23]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:32]([C:34]([O:36]C)=[O:35])=[O:33])=[CH:22][CH:21]=2)[C:7]([C:14]([O:16]CC)=[O:15])=[C:8]([C:10]([OH:13])([CH3:12])[CH3:11])[N:9]=1)[CH3:2].O.[OH-].[Li+]>>[CH2:1]([O:3][CH2:4][C:5]1[N:6]([CH2:19][C:20]2[CH:25]=[CH:24][C:23]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:32]([C:34]([OH:36])=[O:35])=[O:33])=[CH:22][CH:21]=2)[C:7]([C:14]([OH:16])=[O:15])=[C:8]([C:10]([OH:13])([CH3:12])[CH3:11])[N:9]=1)[CH3:2]

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 19378945HCID 19378945, compound

Product 1

HCID 19378987HCID 19378987, compoundYield 67.8%

Procedure

680 mg of ethyl 2-ethoxymethyl-4-(1-hydroxy-1-methylethyl)-1-[(2'-methoxalylbiphenyl-4-yl)methyl]imidazole-5-carboxylate [prepared as described in step (a) above] were subjected to hydrolysis using 224 mg of lithium hydroxide monohydrate in the same manner as described in Example 1(b), to give 423 mg of the title compound as a powder, melting at 138°-140° C.

Sources & evidence

ORD record
ord-6f109e0a7b89405b88c1ecdaa3209a2d
Source dataset
uspto-grants-1995_10
Patent number
US05459148

Reaction notes

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