Lithium hydroxide, monohydrate → HCID 19378954, compound

HRID 2210581Notes

Reaction equation

HRID 2210581 reaction equation
[CH2:1]([C:3]1[N:7]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[C:21]([C:23]([O:25]C)=[O:24])=[O:22])=[CH:11][CH:10]=2)[C:6]2[C:27]([C:31]([O:33]CC)=[O:32])=[CH:28][CH:29]=[CH:30][C:5]=2[N:4]=1)[CH3:2].O.[OH-].[Li+]>>[CH2:1]([C:3]1[N:7]([CH2:8][C:9]2[CH:10]=[CH:11][C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[C:21]([C:23]([OH:25])=[O:24])=[O:22])=[CH:13][CH:14]=2)[C:6]2[C:27]([C:31]([OH:33])=[O:32])=[CH:28][CH:29]=[CH:30][C:5]=2[N:4]=1)[CH3:2]

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 19378984HCID 19378984, compound

Product 1

HCID 19378954HCID 19378954, compoundYield 96.6%

Procedure

300 mg of ethyl 2-ethyl-1-[(2'-methoxalylbiphenyl-4-yl)methyl]benzimidazole-7-carboxylate [prepared as described in step (b) above] were subjected to hydrolysis using 134 mg of lithium hydroxide monohydrate in the same manner as described in Example 17(b), to give 264 mg of the title compound as a powder, melting at 278°-281° C.

Sources & evidence

ORD record
ord-f7081844fee743ecb0ebfef699236373
Source dataset
uspto-grants-1995_10
Patent number
US05459148

Reaction notes

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