Lithium hydroxide, monohydrate → HCID 19378956, compound

HRID 2210582Notes

Reaction equation

HRID 2210582 reaction equation
[CH2:1]([O:3][C:4]1[N:8]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[C:22]([C:24]([O:26]C)=[O:25])=[O:23])=[CH:12][CH:11]=2)[C:7]2[C:28]([C:32]([O:34]CC)=[O:33])=[CH:29][CH:30]=[CH:31][C:6]=2[N:5]=1)[CH3:2].O.[OH-].[Li+]>>[CH2:1]([O:3][C:4]1[N:8]([CH2:9][C:10]2[CH:11]=[CH:12][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[C:22]([C:24]([OH:26])=[O:25])=[O:23])=[CH:14][CH:15]=2)[C:7]2[C:28]([C:32]([OH:34])=[O:33])=[CH:29][CH:30]=[CH:31][C:6]=2[N:5]=1)[CH3:2]

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 19378998HCID 19378998, compound

Product 1

HCID 19378956HCID 19378956, compoundYield 80.8%

Procedure

252 mg of ethyl 2-ethoxy-1-[(2'-methoxalylbiphenyl4-yl)methyl]benzimidazole-7-carboxylate [prepared as described in step (a) above] were subjected to hydrolysis using 136 mg of lithium hydroxide monohydrate in the same manner as described in Example 17(b), to give 186 mg of the title compound as a powder, melting at 158°-161° C.

Sources & evidence

ORD record
ord-5d3235cb37384ff4ae5df2afced10c73
Source dataset
uspto-grants-1995_10
Patent number
US05459148

Reaction notes

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