Hydrogen Peroxide → HCID 14579257, compound

HRID 2210730Notes

Reaction equation

HRID 2210730 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][C:11](=[O:13])[CH3:12])=[CH:5][CH:4]=1)#[N:2].C(=O)(O)[O-:15].[K+].OO>CO.C(=O)([O-])[O-].[K+].[K+]>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][C:11](=[O:13])[CH3:12])=[CH:5][CH:4]=1)(=[O:15])[NH2:2]

Participants

6

Reactant 3

HCID 784Hydrogen PeroxideHCID 516893Potassium BicarbonateHCID 112982374-(3-Oxobutyl)benzonitrile

Product 1

HCID 14579257HCID 14579257, compound

Reagents, catalysts & solvents 2

HCID 11430Potassium CarbonateCatalystHCID 887MethanolSolvent

Procedure

To a stirred solution of 9.70 g (0.056) mole of 4-(4-cyanophenyl)-2-butanone (the product of step (a)) in 15 ml of methanol, 1.80 g of potassium bicarbonate and 0.20 g of potassium carbonate were added. To the resulting mixture, 10.0 ml (0.088 mole) of 30% hydrogen peroxide was added dropwise over an hour. The reaction mixture was stirred for 24 hours and then chilled. The solid was collected by filtration, was rinsed twice with water and was dried to give 9.67 g of the above-identified product, melting point 152°-154° C. The 1H NMR was consistent with the assigned structure.

Workup

  1. temperaturechilled
  2. filtrationThe solid was collected by filtration
  3. washwas rinsed twice with water
  4. customwas dried

Sources & evidence

ORD record
ord-7592502ecdf04c0c86f1da3b55b349a7
Source dataset
uspto-grants-1995_10
Patent number
US05460605

Reaction notes

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