Lithium hydroxide, monohydrate → HCID 19377382, compound

HRID 2210751Notes

Reaction equation

HRID 2210751 reaction equation
C([O:4][CH:5]([C:8]1[C:13]([S:14]([NH:17][C:18]([NH:20][C:21]2[N:26]=[C:25]([O:27][CH3:28])[CH:24]=[C:23]([O:29][CH3:30])[N:22]=2)=[O:19])(=[O:16])=[O:15])=[CH:12][CH:11]=[CH:10][N:9]=1)[CH2:6][F:7])(=O)C.O.[OH-].[Li+]>CO>[F:7][CH2:6][CH:5]([C:8]1[C:13]([S:14]([NH:17][C:18]([NH:20][C:21]2[N:22]=[C:23]([O:29][CH3:30])[CH:24]=[C:25]([O:27][CH3:28])[N:26]=2)=[O:19])(=[O:15])=[O:16])=[CH:12][CH:11]=[CH:10][N:9]=1)[OH:4]

Participants

4

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 19377387HCID 19377387, compound

Product 1

HCID 19377382HCID 19377382, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 0.88 g of 2-(1-acetoxy-2-fluoroethyl)-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-pyridinesulfonamide in 20 ml of methanol is added 0.25 g of lithium hydroxide monohydrate. The mixture is heated to reflux for 1 hour, then allowed to cool and the methanol is evaporated.

Workup

  1. temperatureThe mixture is heated
  2. temperatureto reflux for 1 hour
  3. temperatureto cool
  4. customthe methanol is evaporated

Sources & evidence

ORD record
ord-723d3feebb0349b1a270723f5c2f249d
Source dataset
uspto-grants-1995_10
Patent number
US05461026

Reaction notes

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