HCID 19377381, compound → HCID 19377409, compound

HRID 2210752Notes

Reaction equation

HRID 2210752 reaction equation
[C:1]([O:4][CH:5]([C:8]1[C:9]([S:14]([NH:17]C(C)(C)C)(=[O:16])=[O:15])=[N:10][CH:11]=[CH:12][CH:13]=1)[CH2:6][Cl:7])(=[O:3])[CH3:2]>FC(F)(F)C(O)=O>[C:1]([O:4][CH:5]([C:8]1[C:9]([S:14]([NH2:17])(=[O:15])=[O:16])=[N:10][CH:11]=[CH:12][CH:13]=1)[CH2:6][Cl:7])(=[O:3])[CH3:2]

Participants

3

Reactant 1

HCID 19377381HCID 19377381, compound

Product 1

HCID 19377409HCID 19377409, compoundYield 100.1%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Conditions

Temperature
40 °C

Procedure

3.6 g of 3-(1-acetoxy-2-chloroethyl)-N-(1,1-dimethylethyl)-2-pyridinesulfonamide is added to 20 ml of trifluoroacetic acid and allowed to stir at 40° C. for 12 hours. The acid is evaporated and the crude product is purified by column chromatography to give the subject compound (3 g).

Workup

  1. customThe acid is evaporated
  2. customthe crude product is purified by column chromatography

Sources & evidence

ORD record
ord-50fe62ba3d2e421b992dfdc1d3af9020
Source dataset
uspto-grants-1995_10
Patent number
US05461026

Reaction notes

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