反应详情

To 2-bromododecanoic acid (1 g), after having been dissolved in acetonitrile (50 ml ), were added calcium chloride (2 g) and tetraethylammonium chloride (1 g), and the mixture was heated under reflux for 4 hours. The reaction mixture was filtered, concentrated and distributed into ethyl acetate and water, and the ethyl acetate layer was dried over anhydrous sodium sulfate and concentrated to give 2-chlorododecanoic acid.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 4 hours
3. filtrationThe reaction mixture was filtered
4. concentrationconcentrated
5. dry with materialthe ethyl acetate layer was dried over anhydrous sodium sulfate
6. concentrationconcentrated