反应详情

Propionic acid chloride (17 g, 184 mmol) was added at ambient temperature to a solution of 25 g (174 mmol) 3-aminoquinoline and 26 ml triethyl amine in 400 ml dichloromethane. After stirring for 2 hours in 200 ml 10% sodium carbonate was added and the mixture was shaken and separated. The aqueous phase was extracted 3 times with dichloromethane and 3 times with ethyl acetate. The combined organic phases where dried (magnesium sulfate), filtered and evaporated to yield 35.0 g (100%) of the desired product.

1. additionwas added
2. customseparated
3. extractionThe aqueous phase was extracted 3 times with dichloromethane and 3 times with ethyl acetate
4. dry with materialThe combined organic phases where dried (magnesium sulfate)
5. filtrationfiltered
6. customevaporated