反应详情

To a stirred suspension of zinc dust (0.68 g) activated with hydrochloric acid in THF (15 ml), N-(2-benzylthio-2-methylpropylidene)benzylamine (1.42 g) dissolved in THF (15 ml) and dimethyl 2-bromomethylfumarate (1.28 g) dissolved in THF are added dropwise while refluxing under nitrogen atmosphere. The mixture is stirred for additional 1.5 hours under refluxing. To the mixture saturated aqueous ammonium chloride solution is added. After cooling, the mixture is filtered by celite. A reaction product is extracted with ethyl acetate from the filtrate. The organic layer is washed with 1N hydrochloric acid, water and then saturated sodium chloride solution. The organic layer is dried over anhydrous magnesium sulfate and concentrated in vacuo. The oily residue is purified by silica gel column chromatography to give the titled compound.

1. additionare added dropwise
2. temperaturewhile refluxing under nitrogen atmosphere
3. temperatureunder refluxing
4. temperatureAfter cooling
5. filtrationthe mixture is filtered by celite
6. extractionA reaction product is extracted with ethyl acetate from the filtrate
7. washThe organic layer is washed with 1N hydrochloric acid, water
8. dry with materialThe organic layer is dried over anhydrous magnesium sulfate
9. concentrationconcentrated in vacuo
10. customThe oily residue is purified by silica gel column chromatography