Imidazole → HCID 14884788, compound

HRID 2211110Notes

Reaction equation

HRID 2211110 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([C:12]2[O:13][CH:14]=[CH:15][CH:16]=2)=[N:4][N:3]=1.[NH:17]1[CH:21]=[CH:20][N:19]=[CH:18]1>CN1CCCC1=O>[N:17]1([C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]([C:12]3[O:13][CH:14]=[CH:15][CH:16]=3)=[N:4][N:3]=2)[CH:21]=[CH:20][N:19]=[CH:18]1

Participants

4

Reactant 2

HCID 795ImidazoleHCID 19375603HCID 19375603, compound

Product 1

HCID 14884788HCID 14884788, compoundYield 4.3%

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Conditions

Temperature
150 °C

Procedure

300 mg of 1-chloro-4-(2-furyl)phthalazine and 707 mg of imidazol were dissolved in 2 ml of N-methylpyrrolidone, and the solution was stirred at 150° C. for 10 hours. After the solution was subjected to after-treatment, it was purified by column chromatography, thereby obtaining 14.5 mg of 1-(1-imidazolyl)-4-(2-furyl)phthalazine.

Workup

  1. customwas purified by column chromatography

Sources & evidence

ORD record
ord-31779b57783d4558b1f79e6f59f5ea39
Source dataset
uspto-grants-1995_10
Patent number
US05462941

Reaction notes

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