Hydrochloric Acid → HCID 19375602, compound

HRID 2211113Notes

Reaction equation

HRID 2211113 reaction equation
[C:1]1([C:6]([C:8]2[S:9][CH:10]=[CH:11][C:12]=2[C:13]2[O:14]CC(C)(C)N=2)=[O:7])[S:5][CH:4]=[CH:3][CH:2]=1.Cl.[OH2:21].[Na+].[Cl-]>O1CCOCC1>[C:1]1([C:6]([C:8]2[S:9][CH:10]=[CH:11][C:12]=2[C:13]([OH:14])=[O:21])=[O:7])[S:5][CH:4]=[CH:3][CH:2]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 5234Sodium ChlorideHCID 19375608HCID 19375608, compound

Product 1

HCID 19375602HCID 19375602, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
100 °C

Procedure

2.8 g of 2-(2-thenoyl)-3-(4,4-dimethyl-2-oxazoline-2-yl)thiophene was added to a solution of 30 ml of concentrated hydrochloric acid, 20 ml of water and 20 ml of dioxane, and the solution was stirred at 100° C. for 8 hours. After cooling the solution, an aqueous NaCl solution was added thereto. The resultant solution was extracted with chloroform and dried. After the solvent was distilled off, the residue was purified by silica gel chromatography to obtain 0.70 g of 2-(2-thenoyl)-3-thiophene carboxylic acid.

Workup

  1. temperatureAfter cooling the solution
  2. extractionThe resultant solution was extracted with chloroform
  3. customdried
  4. distillationAfter the solvent was distilled off
  5. customthe residue was purified by silica gel chromatography

Sources & evidence

ORD record
ord-5fceaad458b94cbe9f1c92b87c033e7a
Source dataset
uspto-grants-1995_10
Patent number
US05462941

Reaction notes

Loading…