反应详情

Sodium hydride (103 mg) was added to a stirred solution of tert-butyl hexahydro-3-oxo-1H-1,4-diazepine-1-carboxylate in DMF (5 mL) at 0° C. After 1 h, iodomethane (0.15 mL) was added, and the resultant mixture was stirred at 0° C., then room temperature overnight. It was diluted with saturated aqueous ammonium chloride solution and extracted with ethyl acetate. The organic layer was separated, washed sequentially with saturated aqueous sodium bicarbonate solution and brine, dried over sodium sulfate, and concentrated to give the product, which was used without further purification.

1. customroom temperature overnight
2. extractionextracted with ethyl acetate
3. customThe organic layer was separated
4. washwashed sequentially with saturated aqueous sodium bicarbonate solution and brine
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated
7. customto give the product, which
8. customwas used without further purification