Hydrochloric Acid → HCID 86760229, compound

HRID 2211844Notes

Reaction equation

HRID 2211844 reaction equation
C(OC([NH:8][C@H:9]([CH2:33][C:34]1[CH:39]=[C:38]([F:40])[C:37]([F:41])=[CH:36][C:35]=1[F:42])[CH2:10][C:11]([N:13]1[CH2:19][CH2:18][CH2:17][NH:16][C:15](=[O:20])[C@H:14]1[CH2:21][C:22]1[CH:27]=[CH:26][C:25]([O:28][C:29]([F:32])([F:31])[F:30])=[CH:24][CH:23]=1)=[O:12])=O)(C)(C)C.[ClH:43]>O1CCOCC1>[ClH:43].[NH2:8][C@H:9]([CH2:33][C:34]1[CH:39]=[C:38]([F:40])[C:37]([F:41])=[CH:36][C:35]=1[F:42])[CH2:10][C:11]([N:13]1[CH2:19][CH2:18][CH2:17][NH:16][C:15](=[O:20])[C@H:14]1[CH2:21][C:22]1[CH:23]=[CH:24][C:25]([O:28][C:29]([F:30])([F:31])[F:32])=[CH:26][CH:27]=1)=[O:12]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86595393HCID 86595393, compound

Product 1

HCID 86760229HCID 86760229, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(3R)-4-[(3R)-3-[(tert-Butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoyl]hexahydro-3-[4-(trifluoromethoxy)benzyl]-2H-1,4-diazepin-2-one was dissolved in 4M hydrogen chloride in dioxane and evaporated after 2.5 h to yield the desired product. LC/MS 504.2 (M+1).

Workup

  1. customevaporated after 2.5 h

Sources & evidence

ORD record
ord-c59dbbe93086417e88139df386c4d13e
Source dataset
uspto-grants-2006_09
Patent number
US07101871B2

Reaction notes

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