Tetrahydrofuran → HCID 21963435, compound

HRID 2211891Notes

Reaction equation

HRID 2211891 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][CH2:12][N:13]2[CH2:18][CH2:17][N:16]([C:19]3[C:23]4[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=4[S:21][N:20]=3)[CH2:15][CH2:14]2)=[CH:6][CH:5]=1)([O-])=O.C1COCC1>[Ni].C(N(CC)CC)C>[S:21]1[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[C:19]([N:16]2[CH2:15][CH2:14][N:13]([CH2:12][CH2:11][CH2:10][C:7]3[CH:6]=[CH:5][C:4]([NH2:1])=[CH:9][CH:8]=3)[CH2:18][CH2:17]2)=[N:20]1

Participants

5

Reactant 2

HCID 8028TetrahydrofuranHCID 21963375HCID 21963375, compound

Product 1

HCID 21963435HCID 21963435, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8471TriethylamineSolvent

Procedure

4-[3-(4-1,2-Benzisothiazol-3-yl-piperazin-1-yl)-propyl]-phenylamine was prepared according to the general method as outlined in Preparation 3 starting from 3-{4-[3-(4-nitro-phenyl)-propyl]-piperazin-1-yl}-1,2-benzoisothiazole (0.58 g, 1.52 mmol), 50 mL of THF treated with triethylamine (0.3 mL) and wet Raney nickel (0.56 g). The resultant solid was dried in vacuo (0.535 g, 1.52 mmol). Yield 100%; MS (APCI): 353 [M+H]+.

Workup

  1. customThe resultant solid was dried in vacuo (0.535 g, 1.52 mmol)

Sources & evidence

ORD record
ord-db21e0886fac490d8dc94dc0ccb369da
Source dataset
uspto-grants-2006_09
Patent number
US07101886B2

Reaction notes

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