Iodoethane → N-[4-(2-Chloro-ethyl)-2-methyl-phenyl]-N-ethyl-acetamide

HRID 2211914Notes

Reaction equation

HRID 2211914 reaction equation
[Cl:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:13])[CH3:12])=[C:6]([CH3:14])[CH:5]=1.[CH2:15](I)[CH3:16]>>[Cl:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]([CH2:15][CH3:16])[C:11](=[O:13])[CH3:12])=[C:6]([CH3:14])[CH:5]=1

Participants

3

Reactant 2

HCID 6340IodoethaneHCID 21963464N-[4-(2-Chloro-ethyl)-2-methyl-phenyl]-acetamide

Product 1

HCID 21963286N-[4-(2-Chloro-ethyl)-2-methyl-phenyl]-N-ethyl-acetamideYield 88%

Procedure

N-[4-(2-Chloro-ethyl)-2-methyl-phenyl]-N-ethyl-acetamide was prepared according to the general method as outlined in Preparation 43 starting from N-[4-(2-chloro-ethyl)-2-methyl-phenyl]-acetamide (0.40 g, 1.89 mmol) and ethyliodide (0.189 mL, 2.36 mmol). After chromatographic purification, the product was isolated as a viscous oil (0.399 g, 1.66 mmol).

Workup

  1. customAfter chromatographic purification

Sources & evidence

ORD record
ord-61552842dc6841bd88d5f08d25dfbdea
Source dataset
uspto-grants-2006_09
Patent number
US07101886B2

Reaction notes

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