Phenylacetic Acid → HCID 21962803, compound

HRID 2211983Notes

Reaction equation

HRID 2211983 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.[C:18]1([CH2:24][C:25](O)=[O:26])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>CN1CCCC1=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH:13][C:25](=[O:26])[CH2:24][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:7]1

Participants

4

Reactant 2

HCID 999Phenylacetic AcidHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine

Product 1

HCID 21962803HCID 21962803, compoundYield 72.5%

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

A mixture of Intermediate 1 (0.028 g) and phenylacetic acid (0.015 g) was treated with 1-methyl-2-pyrrolidinone (0.015 ml) then heated in a 600 W microwave oven, at full power, for 4 min. The crude mixture was purified by chromatography on silica gel (Varian Bond-Elut, 1 g) eluting with cyclohexane/ethyl acetate (4:1 followed by 2:1) to give the title compound as a colourless gum (0.029 g).

Workup

  1. temperaturethen heated in a 600 W microwave oven, at full power, for 4 min
  2. customThe crude mixture was purified by chromatography on silica gel (Varian Bond-Elut, 1 g)
  3. washeluting with cyclohexane/ethyl acetate (4:1 followed by 2:1)

Sources & evidence

ORD record
ord-cfea566de03b42c1a137dd3a49c19ee7
Source dataset
uspto-grants-2006_09
Patent number
US07101882B2

Reaction notes

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