Potassium Carbonate → HCID 21963777, compound

HRID 2212084Notes

Reaction equation

HRID 2212084 reaction equation
[C:1]1([S:7]([C:10]2([CH2:13][CH:14]3[CH2:16][O:15]3)[CH2:12][CH2:11]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:23][C:24]1[CH2:25][NH:26][CH2:27][CH2:28][C:29]=1[CH3:30]>C(#N)C>[C:1]1([S:7]([C:10]2([CH2:13][CH:14]([OH:15])[CH2:16][N:26]3[CH2:25][C:24]([CH3:23])=[C:29]([CH3:30])[CH2:28][CH2:27]3)[CH2:12][CH2:11]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 10997188HCID 10997188, compoundHCID 21963750HCID 21963750, compound

Product 1

HCID 21963777HCID 21963777, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Crude 2-(1-benzenesulphonylcyclopropylmethyl)oxirane (500 mg, 2.1 mmol), potassium carbonate (580 mg, 4.2 mmol) and 3,4-dimethyl-1,2,5,6-tetrahydropyridine (470 mg, 4.2 mmol) in acetonitrile (3 ml) were heated at 60° C. for 18 hours. The mixture was purified by preparative thin layer chromatography, eluting with 5% methanol/dichloromethane, to give the title compound.

Workup

  1. customThe mixture was purified by preparative thin layer chromatography
  2. washeluting with 5% methanol/dichloromethane

Sources & evidence

ORD record
ord-58a9a2dab89e401cbd134a929900f801
Source dataset
uspto-grants-2006_09
Patent number
US07101892B2

Reaction notes

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